一种可调控的未变性天然胶原表面活性剂及其制备方法

  • Inventors:
  • Assignees: 四川大学
  • Publication Date: December 28, 2011
  • Publication Number: CN-102294198-A

Abstract

本发明公开了一种可调控的未变性天然胶原表面活性剂及其制备方法,其特征在于该表面活性剂由以下原料组分组成:未变性天然胶原10重量份,长链酸酐1~30重量份,短链二元酸酐2~8重量份,有机溶剂10~500重量份,去离子水50~500重量份。并按以下方法制备:(1)将10重量份冷冻干燥后的未变性天然胶原,1~30重量份长链酸酐浸泡在50~500重量份有机溶剂中,于室温下反应2~10h;(2)将上述反应物置于空气中自然干燥,加入50~500重量份去离子水,用碱调节pH=10~12使其溶解,再缓慢加入短链二元酸酐2~8重量份溶于10~150重量份的有机溶剂中,于室温下反应3~8h。(3)反应结束后用酸调节pH至出现沉淀为止,沉淀物用酸调节pH=4.2~4.6的去离子水洗涤3~5次,获得性能良好的未变性天然胶原表面活性剂。
The invention discloses a controllable unmodified natural collagen surfactant and a preparation method thereof, wherein the surfactant is composed of the following raw material components: 10 parts by weight of unmodified natural collagen, 1-30 parts by weight of long-chain anhydride, 2-8 parts by weight of short-chain binary anhydride, 10-500 parts by weight of organic solvent, and 50-500 parts by weight of de-ionized water; and the surfactant is prepared by a method comprising the following steps of: (1) soaking 10 parts by weight of unmodified natural collagen which is freeze-dried previously and 1-30 parts by weight of long-chain anhydride in 50-500 parts by weight of organic solvent, and carrying out a reaction at the room temperature for 2-10 h; (2) putting the reactants in the air and naturally drying the same, adding 50-500 parts by weight of de-ionized water thereto and regulating pH to a range of 10-12 using base, so that the reactants are dissolved, and then slowly adding 2-8 parts by weight of short-chain binary anhydride to 10-150 parts by weight of organic solvent for dissolving, and reacting at the room temperature for 3-8 h; and (3) after the reaction ends, adjusting the pH using acid until precipitate is present, and washing the precipitate 3-5 times using de-ionized water having a pH from 4.2 to 4.6 regulated using acid, thereby obtaining the unmodified natural collagen surfactant with excellent performance.

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Cited By (1)

    Publication numberPublication dateAssigneeTitle
    CN-106076193-ANovember 09, 2016四川大学以离子液体为反应介质的未变性胶原基生物表面活性剂及其制备方法